The Integrated Science Center, also known as the ISC, is located between Millington Hall and the Jamestown Residences on Barksdale Field. Built at a cost of $128.4 million, the facility was constructed to help integrate the William & Mary's science programs, allowing for increased opportunity for multidisciplinary research. Phase I of the ISC opened in June 2008 and currently houses the Biology, Chemistry, Neuroscience, and Psychology departments.

A second phase of construction, completed in 2009, transformed Rogers Hall, completed in 1975. This second half of the Center contains the remainder of the Biology and Psychology departments. Construction on the third and final phase of the ISC began in 2014 and is scheduled to be completed in the spring of 2016. When completed, ISC 3 will have approximately 113,000 square feet and feature a 300-seat lecture hall, new labs and research facilities. It will also house the Applied Science department and SciClone computer cluster. The third phase will add a greenhouse to the roof of ISC 2.